Abstract Steier, Joerg, Nic Cade, Ben Walker, John Moxham, and Caroline Jolley.
Observational study of neural respiratory drive during sleep at high altitude. High Alt Med
Biol. 18: 242–248, 2017. Aims: Ventilation at altitude changes due to altered levels of pO2,
pCO2 and the effect on blood pH. Nocturnal ventilation is particularly exposed to these
changes. We hypothesized that an increasing neural respiratory drive (NRD) is associated
with the severity of sleep-disordered breathing at altitude. Methods: Mountaineers were …

Aims: Ventilation at altitude changes due to altered levels of pO2, pCO2 and the effect on
blood pH. Nocturnal ventilation is particularly exposed to these changes. We hypothesized
that increasing neural respiratory drive is associated with the severity of sleep-disordered
breathing at altitude. Methods: Mountaineers were studied at sea level (London, UK), and at
altitude at the